abstract：:Projections from the posterior thalamus and medial geniculate body were labeled retrogradely with wheat germ agglutinin conjugated to horseradish peroxidase injected into the rat, cat, and squirrel monkey inferior colliculus. Neurons were found ipsilaterally in the (1) medial division of the medial geniculate body, (2...

journal_title：Hearing research

authors： Winer JA,Chernock ML,Larue DT,Cheung SW

更新日期：2002-06-01 00:00:00

abstract：:Thresholds for responses to tone bursts in the primary auditory field of pentobarbital-anesthetized rat are significantly lower for local field potentials (5.60 dB+/-1.76 S.E.M.) than for multiple unit discharges (17.80 dB+/-3.17), recorded simultaneously from the same microelectrode. The characteristic frequencies (C...

journal_title：Hearing research

authors： Galván VV,Chen J,Weinberger NM

更新日期：2002-05-01 00:00:00

abstract：:In cases of sudden, reversible hearing loss where perilymphatic fistulas are thought to be the cause, a multitude of causes have been postulated. These include perilymphatic pressure changes, Simmons' double-break theory, perilymphatic hemorrhage, pneumolabyrinth, and others. This study was proposed to explore the rol...

journal_title：Hearing research

authors： Foster PK,Luebke AE

更新日期：2002-05-01 00:00:00

abstract：:To examine the reversibility of functional damage to the cochlea after transient ischemia, cochlear ischemia of 0-60 min was induced in 34 albino guinea pigs. Thresholds of auditory brainstem response (ABR) were then followed for 5 days after ischemia. Although the ABR threshold returned to almost the pre-ischemic val...

journal_title：Hearing research

authors： Tsuji S,Tabuchi K,Hara A,Kusakari J

更新日期：2002-04-01 00:00:00

abstract：:This paper describes the development of a protocol that can be used to detect collagen II in the healthy adult basilar membrane (BM) at the electron microscopic level. This protocol required aggressive epitope exposure techniques to break the crosslinks that bind the collagen molecules tightly into fibrils and to remo...

journal_title：Hearing research

authors： Dreiling FJ,Henson MM,Henson OW Jr

更新日期：2002-04-01 00:00:00

abstract：:The frequency-modulation following response (FMFR) is a steady-state evoked response which may be a neural correlate of frequency discrimination. Aged subjects with normal hearing have abnormal frequency discrimination for low carrier frequencies and thus it might be predicted that aged individuals would have reduced ...

journal_title：Hearing research

authors： Boettcher FA,Madhotra D,Poth EA,Mills JH

更新日期：2002-03-01 00:00:00

abstract：:Masking patterns were measured for hearing-impaired subjects with varying degrees of hearing loss. In one set of conditions, three subjects were tested using narrowband noise ('noise') and sinusoidal ('tone') maskers and narrowband noise signals. The maskers had centre frequencies of 0.25, 0.5, 1.0 and 4.0 kHz and lev...

journal_title：Hearing research

authors： Alcántara JI,Moore BC

更新日期：2002-03-01 00:00:00

abstract：:The influence of noise exposure on the endothelial transport system in the cochlea was investigated using cationic polyethyleneimine (PEI), since systemically administered PEI passes through the capillary endothelial cell and attaches to basal lamina (BL) anionic sites in the cochlea. Under general anesthesia, all gui...

journal_title：Hearing research

authors： Suzuki M,Yamasoba T,Ishibashi T,Miller JM,Kaga K

更新日期：2002-02-01 00:00:00

abstract：:In a wide variety of mammals, the rim of the tympanic membrane (annulus fibrosus) has an array of contractile elements, either smooth muscle [Henson and Henson, J. Assoc. Res. Otolaryngol. 1 (2000) 25-32] or myofibroblasts [Kuijpers et al., Hear. Res. 128 (1999) 80-88]. These elements are anchored peripherally to the ...

journal_title：Hearing research

authors： Yang X,Henson OW Jr

更新日期：2002-02-01 00:00:00

abstract：:Peripheral auditory adaptation has been studied extensively in animal models, and multiple exponential components have been identified. This study explores the feasibility of estimating these component processes for human listeners with a peripheral model of adaptation. The processes were estimated from off-frequency ...

journal_title：Hearing research

authors： Formby C,Rutledge JC,Sherlock LP

更新日期：2002-02-01 00:00:00

abstract：:Heat shock protein-27 (Hsp27) is known to function as both a stress-inducible molecular chaperone and regulator of actin polymerization. For many cells in the cochlea, actin is part of the cytoskeleton and plays an important role in the maintenance of cochlear function. To understand the molecular processes by which t...

journal_title：Hearing research

authors： Leonova EV,Fairfield DA,Lomax MI,Altschuler RA

更新日期：2002-01-01 00:00:00

abstract：:This study was aimed at defining the relationship between noise-related hearing impairment in industrial workers exposed to continuous noise. For this malondialdehyde and glutathione peroxidase were analyzed as free radical form and antioxidant form. A total of 60 patients working in the units of a hydroelectric power...

journal_title：Hearing research

authors： Kaygusuz I,Oztürk A,Ustündağ B,Yalçin S

更新日期：2001-12-01 00:00:00

abstract：:We used whole cell voltage clamp recordings from neurones in rat auditory brainstem slices to study the Ca(2+) channel types involved in triggering synaptic glutamate and glycine release in the medial superior olivary nucleus. Glutamate release from the anterior ventral cochlear (aVCN) bushy neurone synapse did not in...

journal_title：Hearing research

authors： Barnes-Davies M,Owens S,Forsythe ID

更新日期：2001-12-01 00:00:00

abstract：:The number, size and distribution of myelinated nerve fibers were analyzed in the osseous spiral lamina (OSL) of young and old gerbils raised in a quiet environment. Because decreased endocochlear potentials (EPs) play a significant role in age-related hearing loss in the gerbil, we correlated morphometric and topogra...

journal_title：Hearing research

authors： Suryadevara AC,Schulte BA,Schmiedt RA,Slepecky NB

更新日期：2001-11-01 00:00:00

abstract：:Studies in several mammalian species have demonstrated that auditory cortical neurons respond strongly to single frequency-modulated (FM) sweeps, and that most responses are selective for sweep direction and/or rate. In the present study, we used extracellular recordings to examine how neurons in the auditory cortices...

journal_title：Hearing research

authors： Orduña I,Mercado E 3rd,Gluck MA,Merzenich MM

更新日期：2001-10-01 00:00:00

abstract：:This study examined the effect of monaural middle ear destruction on postnatal development of auditory response properties of inferior collicular (IC) neurons of the laboratory mouse, Mus musculus. Monaural middle ear destruction was performed on juvenile and adult mice and the auditory response properties of neurons ...

journal_title：Hearing research

authors： Xu L,Jen PH

更新日期：2001-09-01 00:00:00

abstract：:Immunophilin FK binding protein-12 (FKBP-12), the soluble receptor for the immunosuppressant drug FK506, is involved in a number of neuronal activities including increased nerve regeneration in the peripheral nervous system and enhanced recovery in animal models of neurodegenerative diseases. In addition, FKBP-12 is t...

journal_title：Hearing research

authors： Zajic G,Henley C,Louis JC,Nicolson M,Magal E

更新日期：2001-09-01 00:00:00

abstract：:A common problem among the elderly is a difficulty in discriminating speech sounds. One factor that may contribute to this is a deterioration in the ability to process dynamic aspects of speech such as formant transitions. For the aging auditory system, this deterioration in temporal processing speed may be manifest a...

journal_title：Hearing research

authors： Mendelson JR,Ricketts C

更新日期：2001-08-01 00:00:00

abstract：:Immunohistochemical data indicate that OCP1 co-localizes exactly with OCP2 in the epithelial gap junction region of the guinea pig organ of Corti (OC). Despite the abundance of OCP1 in the OC, gaining access to its coding sequence -- and, in particular, the 5' end of the coding sequence -- proved unexpectedly challeng...

journal_title：Hearing research

authors： Henzl MT,O'Neal J,Killick R,Thalmann I,Thalmann R

更新日期：2001-07-01 00:00:00

abstract：:A number of studies have shown that the ear can be protected from sound over-exposure, either by activating the cochlear efferent system, or by sound 'conditioning' in which the role of the efferent system is less certain. To study more definitively the molecular basis of deliberately induced cochlear protection from ...

journal_title：Hearing research

authors： Vázquez AE,Luebke AE,Martin GK,Lonsbury-Martin BL

更新日期：2001-06-01 00:00:00

abstract：:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...

journal_title：Hearing research

authors： Takeuchi S,Ando M,Sato T,Kakigi A

更新日期：2001-05-01 00:00:00

abstract：:A mathematical model of the evolution of statoconia in statocysts of freshwater snails based on the analysis of experimental data [Wiederhold et al., 1990; Pedrozo et al., 1996; Gao et al., 1997; Gao and Wiederhold, 1997; Wiederhold et al., 1999] is proposed. The growth of statoconia is considered as the process of so...

journal_title：Hearing research

authors： Kondrachuk AV

更新日期：2001-04-01 00:00:00

abstract：:Blind cave fish use the lateral line sensory system to detect nearby objects. The fish responds to sudden perturbations in the water column by initiating startle responses in which they swim more rapidly. Normal startle responses disappear after trauma caused by a single 15 s immersion in calcium free water, but retur...

journal_title：Hearing research

authors： Repass JJ,Watson GM

更新日期：2001-04-01 00:00:00

abstract：:Tympanosclerosis is a condition leading to a calcification process in the middle ear, and often develops after chronic inflammation of the middle ear. Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in...

journal_title：Hearing research

authors： Makiishi-Shimobayashi C,Tsujimura T,Sugihara A,Iwasaki T,Yamada N,Terada N,Sakagami M

更新日期：2001-03-01 00:00:00

abstract：:Subjective tinnitus may be defined as the perceptual correlate of altered spontaneous neural activity occurring in the absence of an externally evoking auditory stimulus. Tinnitus can be caused or exacerbated by one or more of five forms of stress. We propose and provide evidence supporting a model that explains, but ...

journal_title：Hearing research

authors： Sahley TL,Nodar RH

更新日期：2001-02-01 00:00:00

abstract：:Thresholds for pure tones embedded in harmonic complexes were measured behaviorally and physiologically for three species of birds, and physiologically in gerbils. The harmonic maskers were generated using the Schroeder-phase algorithm, characterized by monotonically increasing or decreasing phase across frequency. Pr...

journal_title：Hearing research

authors： Dooling RJ,Dent ML,Leek MR,Gleich O

更新日期：2001-02-01 00:00:00

abstract：:Although the tectorial membrane has a key role in the function of the organ of Corti, its structural relationship within the cochlear partition is still not fully characterised. Being an acellular structure, the tectorial membrane is not readily stained with dyes and is thus difficult to visualise. We present here det...

journal_title：Hearing research

authors： Ulfendahl M,Flock A,Scarfone E

更新日期：2001-01-01 00:00:00

abstract：:Localization of calmodulin, a calcium binding protein, was identified in adult gerbil cochleas using paraffin section immunohistochemistry and immunogold electron microscopy with monoclonal antibody against bovine calmodulin. Immunoreactive calmodulin was abundant in inner hair cells (IHCs), outer hair cells (OHCs) an...

journal_title：Hearing research

authors： Nakazawa K

更新日期：2001-01-01 00:00:00

abstract：:Auditory brainstem responses (ABR) to clicks and noise bursts of various frequency bands and intensities were recorded in two bottlenosed dolphins, Tursiops truncatus. The purpose was to assess contributions of various parts of the cochlear partition to ABR and travelling wave velocity in the cochlea. At band-pass fil...

journal_title：Hearing research

authors： Popov VV,Supin AY

更新日期：2001-01-01 00:00:00

abstract：:We investigated the effects of intracochlear electrical stimulation (ICES) on auditory pathways of neonatal rat deafened by daily amikacin injections. Expression of mRNAs encoding ionotropic glutamate receptor subunits such as alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) and N-methyl-D-aspartate (NMDA), and gamma...

journal_title：Hearing research

authors： Liao WH,Van Den Abbeele T,Herman P,Frachet B,Huy PT,Lecain E,Marianowski R

更新日期：2000-12-01 00:00:00

abstract：:In natural environments, temporally complex signals often occur in a background of noise. The neural mechanisms underlying the preservation of temporal sensitivity in background noise are poorly understood. In the present study, we examined the ability of inferior colliculus (IC) units with primary-like and sustained ...

journal_title：Hearing research

authors： Barsz K,Wilson WW,Walton JP

更新日期：2000-12-01 00:00:00

abstract：:Frequency discrimination thresholds were measured from five chinchillas for harmonic tone complexes having a fundamental frequency of 250 Hz. Stimuli consisted of the fundamental frequency and the second through 10th harmonics with individual components added in either cosine phase or random phase. In general, thresho...

journal_title：Hearing research

authors： Shofner WP

更新日期：2000-11-01 00:00:00

abstract：:There is evidence that pentobarbital, a commonly used anesthetic, can affect neuronal activity, but its effects on particular neurons of the dorsal cochlear nucleus (DCN) are not well known. Bursting (complex spiking) spontaneous activity has been observed in the DCN in brain slice preparations and in recordings from ...

journal_title：Hearing research

authors： Chen K,Godfrey DA

更新日期：2000-11-01 00:00:00

abstract：:In order to clarify the otoconia formation and turnover, tetracycline, an antibiotic that precipitates at calcifying fronts and serves as a fluorescent marker, was injected into eggs at different stages of chick embryonic development, as well as into postnatal chicken and into adult animals. The changes in the intensi...

journal_title：Hearing research

authors： Balsamo G,Avallone B,Del Genio F,Trapani S,Marmo F

更新日期：2000-10-01 00:00:00

abstract：:The effects of efferent activation on the otoacoustic emission were measured in anesthetized guinea pigs. The otoacoustic emission (2F(1)-F(2)) was evoked by the conventional method of presenting either two continuous tones or a sinusoidal current to the round window (RW) of the cochlea. The efferent effects on the ac...

journal_title：Hearing research

authors： Ota Y,Dolan DF

更新日期：2000-10-01 00:00:00

abstract：:Within auditory pathways, the intrinsic electrical properties of neurons, and in particular their complement of potassium channels, play a key role in shaping the timing and pattern of action potentials produced by sound stimuli. The Kv9.1 gene encodes a potassium channel alpha subunit that is expressed in a variety o...

journal_title：Hearing research

authors： Richardson FC,Kaczmarek LK

更新日期：2000-09-01 00:00:00

abstract：:Glutamate, gamma aminobutyric acid (GABA) and glycine receptors have different properties depending on the specific subunit combination utilized. The subunit composition of amino acid receptors may help to shape the responses of neurons and can provide a diversity of response properties in different neuronal types and...

journal_title：Hearing research

authors： Sato K,Shiraishi S,Nakagawa H,Kuriyama H,Altschuler RA

更新日期：2000-09-01 00:00:00

abstract：:This paper will review some of the functional changes that occur in the central auditory pathway after the cochlea is damaged by acoustic overstimulation or by carboplatin, an ototoxic drug that selectively destroys inner hair cells (IHCs) in the chinchilla. Acoustic trauma typically impairs the sensitivity and tuning...

journal_title：Hearing research

authors： Salvi RJ,Wang J,Ding D

更新日期：2000-09-01 00:00:00

abstract：:Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence...

journal_title：Hearing research

authors： Holt JC,Pantoja AM,Athas GB,Guth PS

更新日期：2000-08-01 00:00:00

abstract：:The protective efficacy of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) at 1 or 10 microg/ml was assessed in guinea pigs exposed to 4 kHz octave band noise at 115 dB SPL for 5 h. BDNF, NT-3 or artificial perilymph was delivered to the scala tympani via a mini-osmotic pump, beginning 4 days prior ...

journal_title：Hearing research

authors： Shoji F,Miller AL,Mitchell A,Yamasoba T,Altschuler RA,Miller JM

更新日期：2000-08-01 00:00:00